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pentobarbital will minimize the level or outcome of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or result of alprazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.Contraindicated (one)pentobarbital decreases amounts of vandetanib by impacting hepatic